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Title   타액선 절제술 또는 표피성장인자 투여가 실험적 간암발생에 미치는 영향에 대한 면역조직화학적 성상 ( Effect of Sialadenectomy or Administration of Epidermal Growth Factor on Initiation of Hepatoma in Rat )
Publicationinfo   1993 Jan; 025(02): 196-202.
Key_word   Epidermal growth factor, Glutathione transferase, Hepatoma, Hepatocarcico genesis, Solt-Farber model, Sialadenectomy.
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Abstract   This study was performed to elucidate the modifying effect of epidermal growth factor (EGF), one of the potent initiator of cell division, on the rat hepatoma development. The Solt- Farber's hepatocarcicogenesis model by administration of diethylnitrosamine, acetoaminofluo- rene and partial hepatectomy was performed on Sprague-Dawley male rats. Administration of EGF was performed via subcutaneous injection of urogastron(5 mg/animal) three times a week during three weeks. Bilateral sialadenectomy was done to eliminate the secretion of EGF from the salivary gland. Preneoplastic 1esion was monitored by immunohistochemical method using the antibody against placental form of glutathione transferase. The result showed that there was no difference in development of enzyme-altered foci regardless of sialadenectomy or EGF administratian. Although a possibility of false negative result may remain, EGF seems to influence ittie effect in modification of the emengence of enzyme altered foci in Solt-Farber rat hepatoma modeL
저 자   김우호(Woo Ho Kim),김용일(Yong Il Kim)